Abstract
The synthesis of a series of novel 1-[(benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles is described. The compounds were tested for human placental aromatase inhibition in vitro, using [1beta-3H]-androstenedione as the substrate for the aromatase enzyme, the percentage inhibition and IC50 data is included.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminoglutethimide / pharmacology
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Androstenedione / metabolism
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Aromatase / metabolism
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Aromatase Inhibitors*
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Benzofurans / chemistry
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology*
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Female
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Humans
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Inhibitory Concentration 50
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Ketones / chemical synthesis
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Placenta / enzymology
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Pregnancy
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Structure-Activity Relationship
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Tetrazoles / chemistry*
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Triazoles / chemistry*
Substances
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Aromatase Inhibitors
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Benzofurans
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Enzyme Inhibitors
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Ketones
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Tetrazoles
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Triazoles
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Aminoglutethimide
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Androstenedione
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Aromatase